Diabetes
Tocotrienols help in Diabetes Management by improving Glucose Control, reducing Oxidative sStress and Inflammation, protecting all cells and lowering Cardiovascular Risk.
Tocotrienols Improve Blood Sugar Control. They can enhance Insulin Sensitivity by modulating Insulin Signalling Pathways. In some clinical studies, Tocotrienols reduce Fasting Blood Glucose and HbA1c.
Tocotrienols lower Total Cholesterol, LDL, and Triglycerides while improving HDL. This is particularly beneficial for Diabetics, who often have Dyslipidemia (abnormally high cholesterol or fats in the blood).
Tocotrienols suppress Pro-inflammatory Cytokines (TNF-α, IL-6, CRP), which play a role in Insulin Resistance.
Tocotrienols reduce Chronic Inflammation common in type 2 Diabetes.
Tocotrienols are powerful Antioxidants. They neutralize Free Radicals, reducing Oxidative Stress — a key driver of pancreatic β-cell damage and diabetic complications.
Tocotrienols help protect and preserve pancreatic β-cells from Oxidative Stress and inflammatory damage, supporting Insulin Secretion.
Tocotrienols reduce Arterial Plaque formation, & improve Endothelial function. This is important because Cardiovascular Disease is the leading cause of death in Diabetics.
Tocotrienols help prevent or slow Diabetic Neuropathy through Antioxidant and Anti-inflammatory effects.
Studies show Tocotrienols can reduce markers of Kidney and lLver damage in Diabetics, slowing Diabetic Nephropathy and Fatty Liver Disease.
References
Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2023)
https://pmc.ncbi.nlm.nih.gov/articles/PMC10509396/?utm_source=chatgpt.com
Effects of Delta- Tocotrienol Supplementation on Glycemic Control, Oxidative Stress, Inflammatory Biomarkers and miRNA expression in type 2 Diabetes Mellitus: A randomized control trial (2021) htts://pubmed.ncbi.nlm.nih.gov/33899292/
The Role of Tocotrienol in Protecting Against Metabolic Diseases (2019) https://pmc.ncbi.nlm.nih.gov/articles/PMC6429133/?utm_source=chatgpt.com
Efficacy of Oral Mixed Tocotrienols in Diabetic Peripheral Neuropathy A Randomized Clinical Trial (2018) https://jamanetwork.com/journals/jamaneurology/fullarticle/2670747?utm_source=chatgpt.com
Annatto-extracted Tocotrienols improve Glucose Homeostasis and Bone properties in high-fat diet-induced type 2 Diabetic mice by decreasing the Inflammatory Response (2018)
https://www.nature.com/articles/s41598-018-29063-9?utm_source=chatgpt.com
Tocotrienol-rich fraction supplementation reduces Hyperglycemia-induced Skeletal Muscle damage through regulation of Insulin Signaling and Oxidative Stress in type 2 Diabetic mice (2018) https://www.sciencedirect.com/science/article/pii/S0955286317308471?utm_source=chatgpt.com
Effect of Tocotrienols enriched Canola oil on Glycemic Control and Oxidative Status in patients with type 2 Diabetes Mellitus: A randomized double-blind placebo-controlled clinical trial (2015) https://pmc.ncbi.nlm.nih.gov/articles/PMC4621647/?utm_source=chatgpt.com
The Therapeutic impacts of Tocotrienols in type 2 Diabetic patients with Hyperlipidemia (2005) https://www.sciencedirect.com/science/article/pii/S0021915005001656?utm_source=chatgpt.com