Diabetes

Tocotrienols help in Diabetes Management by improving Glucose Control, reducing Oxidative sStress and Inflammation, protecting all cells and lowering Cardiovascular Risk. 

  • Tocotrienols Improve Blood Sugar Control. They can enhance Insulin Sensitivity by modulating Insulin Signalling Pathways. In some clinical studies, Tocotrienols reduce Fasting Blood Glucose and HbA1c. 

  • Tocotrienols lower Total Cholesterol, LDL, and Triglycerides while improving HDL.  This is particularly beneficial for Diabetics, who often have Dyslipidemia (abnormally high cholesterol or fats in the blood).

  • Tocotrienols suppress Pro-inflammatory Cytokines (TNF-α, IL-6, CRP), which play a role in Insulin Resistance.

  • Tocotrienols reduce Chronic Inflammation common in type 2 Diabetes. 

  • Tocotrienols are powerful Antioxidants. They neutralize Free Radicals, reducing Oxidative Stress — a key driver of pancreatic β-cell damage and diabetic complications. 

  • Tocotrienols help protect and preserve pancreatic β-cells from Oxidative Stress and inflammatory damage, supporting Insulin Secretion.

  • Tocotrienols reduce Arterial Plaque formation, &  improve Endothelial function. This is important because Cardiovascular Disease is the leading cause of death in Diabetics.

  • Tocotrienols help prevent or slow Diabetic Neuropathy through Antioxidant and Anti-inflammatory effects.

  • Studies show Tocotrienols can reduce markers of Kidney and lLver damage in Diabetics, slowing Diabetic Nephropathy and Fatty Liver Disease.

References

Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2023)

https://pmc.ncbi.nlm.nih.gov/articles/PMC10509396/?utm_source=chatgpt.com

Effects of Delta- Tocotrienol Supplementation on Glycemic Control, Oxidative Stress, Inflammatory Biomarkers and miRNA expression in type 2 Diabetes Mellitus: A randomized control trial (2021) htts://pubmed.ncbi.nlm.nih.gov/33899292/

The Role of Tocotrienol in Protecting Against Metabolic Diseases (2019) https://pmc.ncbi.nlm.nih.gov/articles/PMC6429133/?utm_source=chatgpt.com

Efficacy of Oral Mixed Tocotrienols in Diabetic Peripheral Neuropathy A Randomized Clinical Trial (2018) https://jamanetwork.com/journals/jamaneurology/fullarticle/2670747?utm_source=chatgpt.com

Annatto-extracted Tocotrienols improve Glucose Homeostasis and Bone properties in high-fat diet-induced type 2 Diabetic mice by decreasing the Inflammatory Response (2018)

https://www.nature.com/articles/s41598-018-29063-9?utm_source=chatgpt.com

Tocotrienol-rich fraction supplementation reduces Hyperglycemia-induced Skeletal Muscle damage through regulation of Insulin Signaling and Oxidative Stress in type 2 Diabetic mice (2018) https://www.sciencedirect.com/science/article/pii/S0955286317308471?utm_source=chatgpt.com

Effect of Tocotrienols enriched Canola oil on Glycemic Control and Oxidative Status in patients with type 2 Diabetes Mellitus: A randomized double-blind placebo-controlled clinical trial (2015) https://pmc.ncbi.nlm.nih.gov/articles/PMC4621647/?utm_source=chatgpt.com

The Therapeutic impacts of Tocotrienols in type 2 Diabetic patients with Hyperlipidemia (2005) https://www.sciencedirect.com/science/article/pii/S0021915005001656?utm_source=chatgpt.com