Skin

The Skin loves Tocotrienols. Oral Tocotrienols “Work from Within” via the skin’s vast Network of tiny Blood Vessels. Your Skin is the Largest Organ in Your Body and its fFatty Layers literally soak up Tocotrienols boosting the Skin’s entire Antioxidant Defense systems. 

  • Tocotrienols Neutralize damaging “Free Radicals” generated by dangerous UV Radiation & hazardous Pollution Exposure. 

  • Delta- Tocotrienol being the smallest-sized Vitamin E molecule  penetrates deeper throughout many Layers of Skin providing stronger protection against Free Radicals and Oxidative Stress.

  • Tocotrienols Work Visually by Reducing Wrinkles & Facial Fine Lines by Preventing the Breakdown of Collagen.

  • Tocotrienols Stimulate Skin Regeneration by Supporting Your Fibroblasts - The abundant delicate Connective Tissue Cells that are crucial for Skin Elasticity.

  • Tocotrienols Inhibit Melanogenesis (the production of Excess Melanin pigment), reducing Hyperpigmentation and the Dark Spots in your Skin. 

  • Tocotrienols Support Even Complexion and Smoother Skin.

  • Tocotrienols Act as your Skin’s Natural Photoprotectors, Limiting DNA damage caused by UVB and UVA Rays. 

  • Tocotrienols Work Synergistically with Sunscreen materials by Reducing your Skin’s Oxidative Stress and Inflammation.

  • Tocotrienol Calms Skin Irritation, Redness, and Swelling and Inflammation constantly as it remains in the Fatty Skin layers.

  • Tocotrienols are Beneficial for Inflammatory Skin conditions such as Eczema, Psoriasis, and Acne.

  • Tocotrienols Improve Lipid (Fatty) Structures in your Skin,  Reducing TransEpidermal Water Loss (TEWL). They enhance skin Hydration and Resilience against External Environmental Stress Factors and Free Radicals.

  • Tocotrienols Accelerate the Recovery of Skin Injuries by Promoting Angiogenesis (new blood vessel growth) and  Promoting Tissue Repair and Maintenance.

  • Tocotrienols Reduce Scar Formation Working from Within.

  • Topically-Applied Tocotrienol - such as in Enriched Serums, Creams, or Oils are limited by Exposure to Direct Sunlight and by Oxidation from Direct Exposure to the Air. 

  • Topically-Applied Tocotrienol has Stability issues as they are exposed to Air, Light, Heat which can degrade Tocotrienols. 

  • A Scar Prevention study showed no significant effect of 5% Topical Tocotrienol on Hypertrophic scars vs placebo over 4 months.

References

Explicating the Multifunctional roles of Tocotrienol and Squalene in promoting Skin Health (2024) https://pmc.ncbi.nlm.nih.gov/articles/PMC11442061/?utm_source=chatgpt.com

Delta-Tocotrienol Improves the Capability of Bone Marrow-derived Mesenchymal Stem Cells in Promoting Wound Healing by Inhibiting BACH1-related Ferroptosis. (2023)

https://pmc.ncbi.nlm.nih.gov/articles/PMC10516898/?utm_source=chatgpt.com 

Tocotrienol-Rich Fraction Attenuates Blue Light-Induced Oxidative Stress and Melanogenesis in B16-F1 Melanocytes via Anti-Oxidative and Anti-Tyrosinase Properties (2023)

https://www.mdpi.com/1422-0067/24/20/15373?utm_source=chatgpt.com

Tocotrienol in the Treatment of Topical Wounds: Recent Updates (2022)

https://www.mdpi.com/1999-4923/14/11/2479?utm_source=chatgpt.com

Vitamin E Delta-Tocotrienol Triggers Endoplasmic Reticulum Stress-mediated Apoptosis in Human Melanoma Cells (2016) https://pubmed.ncbi.nlm.nih.gov/27461002/

Cytotoxicity and Apoptotic Activities of Alpha- Gamma- and Delta- Tocotrienol Isomers on Human Cancer Cells (2014) https://link.springer.com/article/10.1186/1472-6882-14-469?utm_source=chatgpt.com

Tocotrienols Fight Cancer by Targeting Multiple Cell Signaling Pathways (2011) https://genesandnutrition.biomedcentral.com/articles/10.1007/s12263-011-0220-3?utm_source=chatgpt.com

Cytotoxicity of Delta- Tocotrienols from Kielmeyera coriacea against Cancer Cell Lines (2011) https://pubmed.ncbi.nlm.nih.gov/21094611/

Delta- Tocotrienol-mediated Cell Cycle Arrest and Apoptosis in Human Melanoma Cells (2010) https://pubmed.ncbi.nlm.nih.gov/21187473/

Dietary Tocotrienol reduces UVB-induced Skin Damage and Sesamin enhances Tocotrienol effects in Hairless Mice (2008) https://pubmed.ncbi.nlm.nih.gov/18490840/