Cholesterol

Tocotrienols help control cholesterol by blocking Cholesterol Synthesis in the Liver, lowering LDL (bad) Cholesterol, preventing LDL oxidation, reducing Arterial Inflammation, and improving Lipid profiles. Among all isomers, Delta- and Gamma-Tocotrienols show the strongest Cholesterol-lowering activity.

  • Delta- and Gamma- Tocotrienols suppress HMG-CoA reductase, the key enzyme responsible for cholesterol synthesis in the liver. This leads to lower production of LDL cholesterol (the "bad" cholesterol) without the side effects as with Statin drugs.

  • Clinical studies show Tocotrienols can reduce total cholesterol and LDL cholesterol levels in Hypercholesterolemic individuals. LDL particles are less accumulated in arterial walls when cholesterol production is decreased.

  • Tocotrienols can increase HDL ("good" Cholesterol) modestly while lowering LDL, thereby improving the lipid profile. A better HDL/LDL ratio is strongly protective against Atherosclerosis.

  • Tocotrienols are potent antioxidants—50-60 X more powerful than Tocopherols. They prevent oxidative modification of LDL cholesterol, which is the form that triggers Plaque buildup in arteries.

  • Tocotrienols suppress inflammatory mediators such as NF-κB and Cytokines. This helps reduce Vascular Inflammation, which works synergistically with cholesterol-lowering effects to slow down Atherosclerosis.

  • In patients already taking Statins, Tocotrienols enhance the lowering of Cholesterol , often allowing for lower drug doses & reduced side effects.

References

Effects of tTocotrienol-enriched oat supplementation on metabolic profile, nutritional status and health-related quality of life among patients with Metabolic Syndrome (2025) https://pubs.rsc.org/en/content/articlehtml/2025/fo/d4fo03307h?utm_source=chatgpt.com

Short-term intake of Delta- Tocotrienol on lipid profiles in healthy subjects (2024) https://pmc.ncbi.nlm.nih.gov/articles/PMC11782774/?utm_source=chatgpt.com

Delta-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial (2022) https://www.liebertpub.com/doi/10.1089/met.2022.0052?utm_source=chatgpt.com

Therapeutic potential of palm oil vitamin E-derived Tocotrienols in Inflammation and Chronic Diseases: Evidence from preclinical and clinical studies (2022)

https://www.sciencedirect.com/science/article/abs/pii/S0963996922002320?utm_source=chatgpt.com

Tocotrienol Supplementation Led to Higher Serum Levels of Lysophospholipids but Lower Acylcarnitines in Postmenopausal Women: A Randomized Double-Blinded Placebo-Controlled Clinical Trial (2021) https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.766711/full?utm_source=chatgpt.com

The effects of Tocotrienol supplementation on lipid profile: A meta-analysis of randomized controlled trials (2020) https://www.sciencedirect.com/science/article/abs/pii/S0965229920306890?utm_source=chatgpt.com