Radiation Protection

Delta- and Gamma- Tocotrienols are strong Natural Protectors from Radiation Exposure. They reduce Oxidative Stress, Protect DNA, Preserve Bone Marrow and Blood Vessels. They both are able to enhance survival after radiation exposure—without interfering with the cancer-killing effects of Radiation Therapy.

  • Tocotrienols are Natural Protectors of Ionizing Radiation.

  • Ionizing Radiation includes alpha- radiation, beta- radiation, gamma- radiation, X-radiation, Ultra-Violet radiation and neutrons.

  • Tocotrienols, due to their unsaturated side chain of three double bonds, penetrate cell membranes more efficiently than Tocopherols, allowing them to quickly scavenge Free Radicals and Reduce Oxidative Stress.

  • Ionizing Radiation produces large amounts of Free Radicals, esp. Reactive Oxygen Species (ROS).

  • Ionizing Radiation causes breaks in single and double DNA strands and direct chromosomal damages. 

  • Tocotrienols help protect DNA and chromosomes by promoting DNA repair pathways, reducing Mutations.

  •  Radiation induces Cytokine Storms and Inflammation. Tocotrienols suppress NF-κB activation, COX-2, and Inflammatory Mediators. 

  • Delta- and Gamma- Tocotrienols stimulate endothelial Nitric Oxide sSynthase (eNOS), maintaining vascular integrity of blood vessels.

  • Tocotrienols prevent radiation-induced damage to bone marrow and blood vessels, critical for survival. 

  • Tocotrienols promote recovery of white blood cells, platelets, and red blood cells after radiation. 

  • Tocotrienols help increase survival in animal models after otherwise lethal doses of radiation.

  • Tocotrienols modulate Pro- and Anti-apoptotic proteins, reducing unnecessary Cell Death in normal tissues.

  • Delta- & Gamma- Tocotrienols given before radiation exposure significantly improved survival in mice by protecting Hematopoietic and Gastrointestinal systems.

  • Tocotrienols reduce DNA damage markers and Oxidative Stress in irradiated animals.

  • Tocotrienols protected human Lymphocytes and Bone Marrow Stromal Cells from radiation-induced, single or double-strand DNA breaks and chromosomal damage.

  • Tocotrienols are being investigated as Radioprotectors for cancer patients undergoing radiotherapy (to shield their healthy tissues) and for space/nuclear radiation to protect Astronauts, Air Crews, Frequent Flyers, Soldiers, Atomic Energy Plant Workers, Medical Radiologists, Patients.

  • Importantly, Tocotrienols seem to protect normal cells without reducing radiation’s tumor-killing effects.

References

Natural Guardians: Natural Compounds as Radioprotectors in Cancer Therapy (2024)

https://www.mdpi.com/1422-0067/25/13/6937?utm_source=chatgpt.com

Sequential administration of delta-tocotrienol ameliorates radiation-induced myelosuppression in mice and non-human primates through inducing G-CSF production (2024) https://www.sciencedirect.com/science/article/abs/pii/S0006291X24001979?utm_source=chatgpt.com

Impact of dietary ingredients on radioprotection and radiosensitization: a comprehensive review (2024) https://www.tandfonline.com/doi/full/10.1080/07853890.2024.2396558?utm_source=chatgpt.com#abstract

Radioprotective effectiveness of a novel delta-tocotrienol prodrug on mouse hematopoietic system against 60Co gamma-ray irradiation through inducing granulocyte-colony stimulating factor production (2024)

https://pubmed.ncbi.nlm.nih.gov/38518524/

Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023)

https://pmc.ncbi.nlm.nih.gov/articles/PMC10668991/?utm_source=chatgpt.com

Gamma-tocotrienol, a radiation countermeasure, reverses proteomic changes in serum following total-body gamma irradiation in mice (2022)

https://www.nature.com/articles/s41598-022-07266-5?utm_source=chatgpt.com

Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans) (2018)

https://www.mdpi.com/2076-3921/7/2/33?utm_source=chatgpt.com

Radioprotective efficacy of delta-tocotrienol, a vitamin E isoform, is mediated through granulocyte colony-stimulating factor (2014)

https://digitalcommons.unl.edu/usuhs/146/?utm_source=chatgpt.com

Vitamin E: Tocopherols and Tocotrienols as Potential Radiation Countermeasures (2013)

https://academic.oup.com/jrr/article/54/6/973/1131208?utm_source=chatgpt.com&login=false

Delta- Tocotrienol as a Radioprotective Countermeasure Agent (2009) - World Patent WO2009126866A2 https://patents.google.com/patent/WO2009126866A2/en