Brain

Delta-tocotrienol protects Neurons (nerve cells) against Oxidative Stress, Glutamate Toxicity, and Free Radical damage. It stabilizes mitochondrial function, reducing Neuronal cell death in Stroke, ischemia (low blood supply), & neurodegeneration of nerve cells.
Delta- Tocotrienol suppresses Pro-inflammatory pathways (NF-κB, COX-2, iNOS) in Brain tissue and lowers Microglial Overactivation, which is a driver of both Alzheimer’s and Parkinson’s Diseases.
Delta -Tocotrienols help maintain BBB integrity, reducing Permeability during Oxidative or Inflammatory Stress. This is crucial in conditions like Alzheimer’s disease, Multiple Sclerosis, and Stroke.
Delta- Tocotrienol reduces Brain Infarct (tissue death) lesions size after Ischemic events. It inhibits 12-Lipoxygenase, an enzyme that is known to contribute to Stroke-Induced Neuronal Cell Death.
Tocotrienols reduce Amyloid-β Aggregation and Oxidative Stress, both involved and central to Alzheimer’s disease. Early evidence suggests Tocotrienols can preserve Memory and Learning.
Delta- Tocotrienol downregulates HMG-CoA Reductase (the same enzyme targeted by Statin drugs), thus lowering cholesterol synthesis. Since Cholesterol Dysregulation is linked to Dementia and Stroke, this Delta- Tocotrienol may benefit brain health.
Preclinical studies suggest Tocotrienols may promote White Matter Integrity and Nerve Repair after Injury.

Shifting Perspectives on the Role of Tocotrienol vs. Tocopherol in Brain Health: A Scoping Review (2025) https://www.mdpi.com/1422-0067/26/13/6339?utm_source=chatgpt.com

Scoping Review: The Role of Tocotrienol-Rich Fraction as a Potent Neuroprotective Agent (2025) https://pmc.ncbi.nlm.nih.gov/articles/PMC12386706/?utm_source=chatgpt.com

An examination into the Effects of Tocotrienols (TheraPrimE® rice) on Cognitive Abilities and Sleep in Healthy Adults: a randomised, double-blind, placebo-controlled trial (2025) https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1621516/full?utm_source=chatgpt.com

Tocotrienols Prevent the Decline of Learning Ability in High-Fat, High-Sucrose Diet-Fed C57BL/6 Mice (2024) https://pmc.ncbi.nlm.nih.gov/articles/PMC10971311/?utm_source=chatgpt.com

α-Tocotrienol Protects Neurons by Preventing Tau Hyperphosphorylation via Inhibiting Microtubule Affinity-Regulating Kinase Activation (2024)

Tocotrienol-rich fraction enhances cell proliferation and memory formation in Hippocampal HT22 neuronal cells through BDNF/TrkB pathway (2024)

Effect of Astaxanthin- and Tocotrienol-containing foods on the Ocular function of healthy individuals: A randomized, placebo-controlled, double-blind, parallel-group trial (2024) https://www.sciencedirect.com/science/article/pii/S1756464624004584?utm_source=chatgpt.com

Revisiting the Therapeutic Potential of Tocotrienol (2022)

An open-label, single-arm pilot study of Tocotrienols supplementation on improving memory and attention in healthy young adults (2022)