Inflammation Abatement

Tocotrienols help abate Inflammation by blocking NF-κB Signaling, reducing Cytokines, lowering Oxidative Stress, and downregulating Pro-inflammatory Enzymes.

  • Tocotrienols inhibit the NF-κB pathway which is a central regulator of Inflammation that triggers Cytokine release (TNF-α, IL-6, IL-1β).

  • Delta- and Gamma- Tocotrienols suppress NF-κB activation, reducing downstream Pro-inflammatory Gene Expression.

  • Tocotrienol supplementation lowers circulating levels of C-reactive protein (CRP), TNF-α, IL-6, and IL-8. This helps reduce systemic low-grade inflammation linked to chronic diseases.

  • Tocotrienols downregulate Cyclooxygenase-2 (COX-2) and inducible Nitric Oxide Synthase (iNOS), both enzymes responsible for producing inflammatory mediators (Prostaglandins, Nitric Oxide).

  • Tocotrienols are potent Antioxidants, scavenging fFree Radicals and protecting lipids, proteins, and DNA from Oxidative damage. This dampens ROS-driven inflammatory cascades.

  • Tocotrienols reduce Cholesterol and Triglycerides, indirectly lowering inflammation since Dyslipidemia fuels Vascular and Systemic Inflammation.

  • Tocotrienols protect against Microglial Overactivation in the brain, reducing Neuroinflammation—a contributor to Neurodegenerative diseases like Alzheimer’s. 

  • Tocotrienol supplementation decreased CRP (C-Reactive Protein) and pro-inflammatory Cytokines, improving metabolic profiles. 

  • Tocotrienols reduced Inflammatory markers and improved mobility in Osteoarthritis and Joint Inflammation.

  • Delta- Tocotrienol showed protection against Lipopolysaccharide (LPS) - induced Neuroinflammation in preclinical models.

References

Effects of Tocotrienol on Cardiovascular Risk Markers in Patients With Chronic Kidney Disease: A Randomized Controlled Trial (2025)

https://pmc.ncbi.nlm.nih.gov/articles/PMC11745556/?utm_source=chatgpt.com

Tocotrienol-Enriched Beverage Enhances Psychological Well-Being, Antioxidant Defense, and Genomic Stability in Older Adults: A Randomized Controlled Trial (2025)

https://pmc.ncbi.nlm.nih.gov/articles/PMC12251267/?utm_source=chatgpt.com

An examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial (2025) https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1621516/full?utm_source=chatgpt.com

Health Benefits of Palm Tocotrienol-Rich Fraction: A Systematic Review of Randomized Controlled Trials (2025) https://pubmed.ncbi.nlm.nih.gov/38916919/

Updates in the skeletal and joint protective effects of tocotrienol: a mini review (2024) https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1417191/full?utm_source=chatgpt.com

Revisiting the therapeutic potential of tocotrienol (2022)

https://pmc.ncbi.nlm.nih.gov/articles/PMC9544065/?utm_source=chatgpt.com

Delta-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial (2022) https://www.liebertpub.com/doi/10.1089/met.2022.0052?utm_source=chatgpt.com

Vitamin E Delta- Tocotrienol inhibits TNF-α-stimulated NF-κB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides (2020) https://pmc.ncbi.nlm.nih.gov/articles/PMC6363855/?utm_source=chatgpt.com

Vitamin E Gamma- Tocotrienol inhibits cytokine-stimulated NF-κB activation by induction of anti-inflammatory A20 via stress adaptive response due to modulation of sphingolipids (2016)

https://pmc.ncbi.nlm.nih.gov/articles/PMC4475472/?utm_source=chatgpt.com