Inflammation Abatement
Tocotrienols help abate Inflammation by blocking NF-κB Signaling, reducing Cytokines, lowering Oxidative Stress, and downregulating Pro-inflammatory Enzymes.
Tocotrienols inhibit the NF-κB pathway which is a central regulator of Inflammation that triggers Cytokine release (TNF-α, IL-6, IL-1β).
Delta- and Gamma- Tocotrienols suppress NF-κB activation, reducing downstream Pro-inflammatory Gene Expression.
Tocotrienol supplementation lowers circulating levels of C-reactive protein (CRP), TNF-α, IL-6, and IL-8. This helps reduce systemic low-grade inflammation linked to chronic diseases.
Tocotrienols downregulate Cyclooxygenase-2 (COX-2) and inducible Nitric Oxide Synthase (iNOS), both enzymes responsible for producing inflammatory mediators (Prostaglandins, Nitric Oxide).
Tocotrienols are potent Antioxidants, scavenging fFree Radicals and protecting lipids, proteins, and DNA from Oxidative damage. This dampens ROS-driven inflammatory cascades.
Tocotrienols reduce Cholesterol and Triglycerides, indirectly lowering inflammation since Dyslipidemia fuels Vascular and Systemic Inflammation.
Tocotrienols protect against Microglial Overactivation in the brain, reducing Neuroinflammation—a contributor to Neurodegenerative diseases like Alzheimer’s.
Tocotrienol supplementation decreased CRP (C-Reactive Protein) and pro-inflammatory Cytokines, improving metabolic profiles.
Tocotrienols reduced Inflammatory markers and improved mobility in Osteoarthritis and Joint Inflammation.
Delta- Tocotrienol showed protection against Lipopolysaccharide (LPS) - induced Neuroinflammation in preclinical models.
References
Effects of Tocotrienol on Cardiovascular Risk Markers in Patients With Chronic Kidney Disease: A Randomized Controlled Trial (2025)
https://pmc.ncbi.nlm.nih.gov/articles/PMC11745556/?utm_source=chatgpt.com
Tocotrienol-Enriched Beverage Enhances Psychological Well-Being, Antioxidant Defense, and Genomic Stability in Older Adults: A Randomized Controlled Trial (2025)
https://pmc.ncbi.nlm.nih.gov/articles/PMC12251267/?utm_source=chatgpt.com
An examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial (2025) https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1621516/full?utm_source=chatgpt.com
Health Benefits of Palm Tocotrienol-Rich Fraction: A Systematic Review of Randomized Controlled Trials (2025) https://pubmed.ncbi.nlm.nih.gov/38916919/
Updates in the skeletal and joint protective effects of tocotrienol: a mini review (2024) https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1417191/full?utm_source=chatgpt.com
Revisiting the therapeutic potential of tocotrienol (2022)
https://pmc.ncbi.nlm.nih.gov/articles/PMC9544065/?utm_source=chatgpt.com
Delta-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial (2022) https://www.liebertpub.com/doi/10.1089/met.2022.0052?utm_source=chatgpt.com
Vitamin E Delta- Tocotrienol inhibits TNF-α-stimulated NF-κB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides (2020) https://pmc.ncbi.nlm.nih.gov/articles/PMC6363855/?utm_source=chatgpt.com
Vitamin E Gamma- Tocotrienol inhibits cytokine-stimulated NF-κB activation by induction of anti-inflammatory A20 via stress adaptive response due to modulation of sphingolipids (2016)
https://pmc.ncbi.nlm.nih.gov/articles/PMC4475472/?utm_source=chatgpt.com