Osteoporosis
Tocotrienols protect against Osteoporosis by Reducing Oxidative Stress and Inflammation, Stimulating Bone Formation, and Inhibiting Bone Resorption.
Tocotrienols are potent Anti-Oxidants that reduce Bone Degradation by neutralizing Oxidative Stress caused by Free Radicals.
Tocotrienols suppress Pro-inflammatory Cytokines (e.g., TNF-α, IL-6), thus lowering inflammation-induced bone breakdown. Chronic low-grade inflammation promotes Osteoclast (bone resorption) activity.
Tocotrienols stimulate Osteoblast activity (cells that build bone), thus improving clinical markers of bone formation such as Alkaline Phosphatase and Osteocalcin.
Tocotrienols enhance Calcium deposition in bones.
In animal studies, Tocotrienols reduce Bone resorption by inhibiting Osteoclast differentiation and activity.
Tocotrienols help preserve Trabecular (spongy) and Cortical (hard) bone structure.
Postmenopausal Osteoporosis is linked to Estrogen deficiency.
Tocotrienols may mimic some Estrogenic protective effects on bone without the risks of Hormone Replacement Therapy.
Tocotrienols enhance the effect of Calcium and vitamin D supplementation by improving Bone Metabolism and reducing Oxidative damage.
References
Updates in the Skeletal and Joint Protective Effects of Tocotrienol: a Mini Review (2024) https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1417191/full?utm_source=chatgpt.com
Tocotrienol as a Protecting Agent against Glucocorticoid-Induced Osteoporosis: A Mini Review of Potential Mechanisms (2022)
https://www.mdpi.com/1420-3049/27/18/562?utm_source=chatgpt.com
Tocotrienol Supplementation Led to Higher Serum Levels of Lysophospholipids but Lower Acylcarnitines in Postmenopausal Women: A Randomized Double-Blinded Placebo-Controlled Clinical Trial (2021) https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.766711/full?utm_source=chatgpt.com
Therapeutic potential of Annatto Tocotrienol with self-emulsifying drug delivery system in a rat model of postmenopausal bone loss (2021)
https://www.sciencedirect.com/science/article/pii/S0753332221001530?utm_source=chatgpt.com
Osteoprotective Effects in Postmenopausal Osteoporosis Rat Model: Oral Tocotrienol vs. Intraosseous Injection of Tocotrienol-Poly Lactic-Co-Glycolic Acid Combination (2021)
https://pmc.ncbi.nlm.nih.gov/articles/PMC8637158/?utm_source=chatgpt.com
Tocotrienol supplementation suppressed Bone Resorption and Oxidative Stress in Postmenopausal Osteopenic Women: a 12-week randomized double-blinded placebo-controlled trial (2018)
https://pubmed.ncbi.nlm.nih.gov/29330573/
The biological effects of tocotrienol on bone: a review on evidence from rodent models (2015) https://pmc.ncbi.nlm.nih.gov/articles/PMC4396581/?utm_source=chatgpt.com
γ-Tocotrienol protects against ovariectomy-induced bone loss via mevalonate pathway as HMG-CoA reductase inhibitor (2014)
https://pubmed.ncbi.nlm.nih.gov/25019595/
Effects of Low-Dose versus High-Dose γ-Tocotrienol on the Bone Cells Exposed to the Hydrogen Peroxide-Induced Oxidative Stress and Apoptosis (2012)
https://pmc.ncbi.nlm.nih.gov/articles/PMC3432387/?utm_source=chatgpt.com
α-Tocotrienol inhibits osteoclastic bone resorption by suppressing RANKL expression and signaling and bone resorbing activity (2011).
https://www.sciencedirect.com/science/article/abs/pii/S0006291X11002907?utm_source=chatgpt.com