Tocotrienols & Cancer Research

Explore published studies examining tocotrienols in cancer research. These studies do not establish that tocotrienol supplements prevent or treat cancer. Visit each source for its methods, findings, and limitations.

General Cancer

• Journal of Integrative Medicine (2024) - Tocotrienol isoforms: The molecular mechanisms underlying their effects in cancer therapy and their implementation in clinical trials

• Phytotherapy Research (2024) - Therapeutic potential of tocotrienols as chemosensitizers in cancer therapy

• Biomedicine & Pharmacotherapy (2024) - Delta-tocotrienol disrupts PD-L1 glycosylation and reverses PD-L1-mediated immune suppression

• Monash University (2023) - Anticancer activities of tocotrienols: A Systematic Scoping Review

• Food & Function (2021) - δ-Tocotrienol induces apoptosis and inhibits proliferation of nasopharyngeal carcinoma cells‍ ‍

• European Journal of Nutrition (2020) - Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols

• International Journal of Molecular Sciences (2019) - Molecular Mechanisms of Action of Tocotrienols in Cancer: Recent Trends and Advancements

• Nutrients (2019) - The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines

• Pharmacological Research (2018) - Tocotrienols: The promising analogues of vitamin E for cancer therapeutics

Breast Cancer

• Clinical Nutrition ESPEN (2023) - Chemopreventive and anti-tumor potential of vitamin E in preclinical breast cancer studies: A systematic review

• Scientific Reports (2023) - Phase II trial of delta-tocotrienol in neoadjuvant breast cancer with evaluation of treatment response using ctDNA

• Current Molecular Pharmacology (2022) - Gamma-Tocotrienol Synergistically Promotes the Anti-proliferative and Pro-apoptotic Effects of Etoposide on Breast Cancer Cell Lines

• Antioxidants (2021) - Tocotrienols as an Anti Breast Cancer Agent

• The Journal of Steroid Biochemistry and Molecular Biology (2021) - γ-Tocotrienol reverses multidrug resistance of breast cancer cells through the regulation of the γ-Tocotrienol-NF-κB-P-gp axis

• Biomolecules (2019) - Advancing the Role of Gamma-Tocotrienol as Proteasomes Inhibitor: A Quantitative Proteomic Analysis of MDA-MB-231 Human Breast Cancer Cells

• Nutrition and Cancer (2019) - γ-Tocotrienol Suppression of the Warburg Effect Is Mediated by AMPK Activation in Human Breast Cancer Cells

• Nutrients (2019) - Omega 3-DHA and Delta-Tocotrienol Modulate Lipid Droplet Biogenesis and Lipophagy in Breast Cancer Cells: the Impact in Cancer Aggressiveness

• International Journal of Clinical Experimental Medicine (2015) - miR-429 mediates δ-tocotrienol-induced apoptosis in triple-negative breast cancer cells by targeting XIAP

Colon Cancer

• Acta Oncologica (2023) - Delta tocotrienol as a supplement to FOLFOXIRI in first-line treatment of metastatic colorectal cancer. A randomized, double-blind, placebo-controlled phase II study

• Nutrients (2021) - Clinically Relevant Genes and Proteins Modulated by Tocotrienols in Human Colon Cancer Cell Lines: Systematic Scoping Review

• Cancer Prevention Research (2019) - Chemoprevention of Azoxymethane-induced Colon Carcinogenesis by Delta-Tocotrienol

• Cancer Research (2016) - Vitamin E delta-tocotrienol targets human colon cancer stem cells and inhibits colon cancer metastasis and induces apoptosis

Lung Cancer

• Journal of Herbmed Pharmacology (2019) - Potentiation of in vitro apoptotic effects of δ-Tocotrienol and Jerantinine A on human lung adenocarcinoma cells

• Metabolites (2019) - Delta-Tocotrienol Modulates Glutamine Dependence by Inhibiting ASCT2 and LAT1 Transporters in Non-Small Cell Lung Cancer (NSCLC) Cells: A Metabolomic Approach

• OncoTargets & Therapy (2018) - Delta-tocotrienol inhibits non-small-cell lung cancer cell invasion via the inhibition of NF-κB, uPA activator, and MMP-9

Ovarian Cancer

• IJPRAS (2024) - A Review of the Effects of Vitamin E in Ovarian Cancer

• Cell Proliferation (2021) - δ-Tocotrienol sensitizes and re-sensitizes ovarian cancer cells to cisplatin via induction of G1 phase cell cycle arrest and ROS/MAPK-mediated apoptosis

• Clarity (2019) - The First-Ever Clinical Trial Using Tocotrienols with Ovarian Cancer Patients, Increased their Survival by Seventy Percent in Refractory Ovarian Cancer

• Pharmacological Research (2019) - Delta tocotrienol in recurrent ovarian cancer. A phase II trial

• International Journal of Molecular Science (2016) - Tocotrienol Nanoemulsion Platform of Curcumin Elicit Elevated Apoptosis and Augmentation of Anticancer Efficacy against Breast and Ovarian Carcinomas

Pancreatic Cancer

• World Journal of Gastrointestinal Oncology (2023) - Vitamin E in the management of pancreatic cancer: A scoping review

• Nanomedicine (2021) - Co-Encapsulation of Gemcitabine and Tocotrienols in Nanovesicles Enhanced Efficacy in Pancreatic Cancer

• Cancer Cell International (2019) - Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

• BMC Cancer (2018) - γ-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport

• Oncotarget (2017) - δ-Tocotrienol, a natural form of vitamin E, inhibits pancreatic cancer stem-like cells and prevents pancreatic cancer metastasis

Prostate Cancer

• Advances in Nutrition (2024) - Different Roles of Natural Forms of Vitamin E in Chemoprevention and Treatment of Prostate Cancer

• International Journal of Molecular Science (2023) - Necroptosis Induced by Delta-Tocotrienol Overcomes Docetaxel Chemoresistance in Prostate Cancer Cells

• Cancer Prevention Research (2022) - δ-Tocotrienol is the Most Potent Vitamin E Form in Inhibiting Prostate Cancer Cell Growth and Inhibits Prostate Carcinogenesis in Ptenp−/− Mice

• BMC Cancer (2020) - Upregulation of pERK and c-JUN by γ-tocotrienol and not α-tocopherol are essential to the differential effect on apoptosis in prostate cancer cells

• Free Radical Biology and Medicine (2020) - Mitochondrial functional and structural impairment is involved in the antitumor activity of δ-tocotrienol in prostate cancer cells

• Cell Proliferation (2019) - δ-Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells

• International Journal of Molecular Science (2019) - Gamma-Tocotrienol Induces Apoptosis in Prostate Cancer Cells by Targeting the Ang-1/Tie-2 Signalling Pathway

• International Institute of Anticancer Research (2018) - Suppressive Effect of Delta-Tocotrienol on Hypoxia Adaptation of Prostate Cancer Stem-like Cells