Immune Support
Tocotrienols Enhance Immunity by Protecting Immune Cells from Oxidative Stress, Reducing Chronic Inflammation, Modulating Cytokine Signaling, and Supporting both Innate and Adaptive Immune Functions.
Tocotrienols are Potent Antioxidants that Reduce Oxidative Stress.
A Strong Antioxidant Defense Enhances Overall Cell Immunity.
Tocotrienols Protect Immune Cells (Lymphocytes, Macrophages, etc.) from Free Radical Damage, Preserving their Immune Functions.
Tocotrienols Suppress Pro-inflammatory Pathways such as NF-κB and COX-2, which are Overactive in Chronic Inflammation.
Tocotrienols Lower Excessive Inflammation, helping Maintain a Balanced Immune Response and Preventing Immune Overdrive (Autoimmunity or Chronic Inflammation).
Tocotrienols Modulate and Regulate Cytokines - small proteins produced by our Immune Cells - e.g. IL-6, TNF-alpha. IL-1beta.
Tocotrienols Help the Immune System Respond Appropriately to Pathogens and Foreign Invaders, Without Causing Collateral Damage to the Surrounding Tissues.
Tocotrienols Enhance the Activity of Natural Killer (NK) Cells.
NK cells are Critical in Early Defense Against Viruses and in Identifying Abnormal cells (including Cancer cells).
Animal studies reveal Tocotrienols may Improve NK Cell Cytotoxicity and its Ability to Kill Foreign Invaders.
Tocotrienols can Enhance T-lymphocyte and B-lymphocyte Functions.
This improves the Body’s Immune Memory and its Ability to Respond Faster to Infections after Prior Exposure &/or Vaccination.
Tocotrienols Provide Anti-Cancer Immune Support.
Tocotrienols not only Directly Inhibit Cancer Cell Growth but also Support Immune Surveillance Against Cancers.
Delta- and Gamma- Tocotrienols can Induce Apoptosis in Malignant Cancer Cells while Sparing Healthy Immune Cells.
Tocotrienols Provide Gut-Immune Axis Support.
Some research suggests Tocotrienols help Maintain Gut Barrier Integrity and Reduce Endotoxin-induced Immune Stress.
Since ~70% of Immune Function is Linked to the Gut, this is a Significant Pathway of Tocotrienols in Immune Support.
Delta- and Gamma- Tocotrienols are especially Promising in Anti-inflammatory conditions, Infections, & Cancer Immune Defense.
References
Delta- Tocotrienol Disrupts PD-L1 Glycosylation and Reverses PD-L1-Mediated Immune Suppression (2024) https://www.sciencedirect.com/science/article/pii/S0753332223018760?utm_source=chatgpt.com
Effects of Tocotrienols Supplementation on Markers of Inflammation and Oxidative Stress: A SystematicReview and Meta-analysis of Randomized Controlled Trials (2021)
https://pmc.ncbi.nlm.nih.gov/articles/PMC8301652/?utm_source=chatgpt.com
Investigation of the Curative Effects of Palm Vitamin E Tocotrienols on Autoimmune Arthritis Disease in vivo (2019) https://www.nature.com/articles/s41598-019-53424-7?utm_source=chatgpt.com
Regulatory Role of Vitamin E in the Immune System and Inflammation (2018) https://pmc.ncbi.nlm.nih.gov/articles/PMC7011499/?utm_source=chatgpt.com
Biological Properties of Tocotrienols: Evidence in Human Studies (2016) https://www.mdpi.com/1422-0067/17/11/1682?utm_source=chatgpt.com
Role of Immunoregulatory Transcription Factors in Differential Immunomodulatory Effects of Tocotrienols (2011) https://www.sciencedirect.com/science/article/abs/pii/S0891584911002115?utm_source=chatgpt.com
Delta- Tocotrienol Protects Mouse and Human Hematopoietic Progenitors from Gamma-Irradiation Through Extracellular Signal-regulated Kinase/Mammalian Target of Rapamycin Signaling (2010) https://haematologica.org/article/view/5806?utm_source=chatgpt.com
Dietary Supplementation with Tocotrienols Enhances Immune Function in C57BL/6 Mice (2010) https://pubmed.ncbi.nlm.nih.gov/20484546/
Daily Supplementation of Tocotrienol-rich Fraction or Alpha- Tocopherol Did Not Induce Immunomodulatory Changes in Healthy Human Volunteers (2009) https://pubmed.ncbi.nlm.nih.gov/18702848/
Tocotrienols Suppress Proinflammatory Markers and Cyclooxygenase-2 Expression in RAW264.7 Macrophages (2009) https://pubmed.ncbi.nlm.nih.gov/19655189/
γ-Tocotrienol Inhibits Nuclear Factor-κB Signaling Pathway through Inhibition of Receptor-interacting Protein and TAK1 Leading to Suppression of Antiapoptotic Gene Products and Potentiation of Apoptosis (2007) https://www.jbc.org/article/S0021-9258%2820%2979870-4/fulltext?utm_source=chatgpt.com