Immune Support

Tocotrienols Enhance Immunity by Protecting Immune Cells from Oxidative Stress, Reducing Chronic Inflammation, Modulating Cytokine Signaling, and Supporting both Innate and Adaptive Immune Functions. 

  • Tocotrienols are Potent Antioxidants that Reduce Oxidative Stress.

  • A Strong Antioxidant Defense Enhances Overall Cell Immunity.

  • Tocotrienols Protect Immune Cells (Lymphocytes, Macrophages, etc.) from Free Radical Damage, Preserving their Immune Functions.

  • Tocotrienols Suppress Pro-inflammatory Pathways such as NF-κB and COX-2, which are Overactive in Chronic Inflammation.

  • Tocotrienols Lower Excessive Inflammation, helping Maintain a Balanced Immune Response and Preventing Immune Overdrive (Autoimmunity or Chronic Inflammation).

  • Tocotrienols Modulate and Regulate Cytokines - small proteins produced by our Immune Cells - e.g. IL-6, TNF-alpha. IL-1beta.

  • Tocotrienols Help the Immune System Respond Appropriately to Pathogens and Foreign Invaders, Without Causing Collateral Damage to the Surrounding Tissues. 

  • Tocotrienols Enhance the Activity of Natural Killer (NK) Cells.

  • NK cells are Critical in Early Defense Against Viruses and in Identifying Abnormal cells (including Cancer cells).

  • Animal studies reveal Tocotrienols may Improve NK Cell Cytotoxicity and its Ability to Kill Foreign Invaders.

  • Tocotrienols can Enhance T-lymphocyte and B-lymphocyte Functions.

  • This improves the Body’s Immune Memory and its Ability to Respond Faster to Infections after Prior Exposure &/or Vaccination.

  • Tocotrienols Provide Anti-Cancer Immune Support.

  • Tocotrienols not only Directly Inhibit Cancer Cell Growth but also Support Immune Surveillance Against Cancers.

  • Delta- and Gamma- Tocotrienols can Induce Apoptosis in Malignant Cancer Cells while Sparing Healthy Immune Cells.

  • Tocotrienols Provide Gut-Immune Axis Support.

  • Some research suggests Tocotrienols help Maintain Gut Barrier Integrity and Reduce Endotoxin-induced Immune Stress.

  • Since ~70% of Immune Function is Linked to the Gut, this is a Significant Pathway of Tocotrienols in Immune Support.

  • Delta- and Gamma- Tocotrienols are especially Promising in Anti-inflammatory conditions, Infections, & Cancer Immune Defense.

References

Delta- Tocotrienol Disrupts PD-L1 Glycosylation and Reverses PD-L1-Mediated Immune Suppression (2024) https://www.sciencedirect.com/science/article/pii/S0753332223018760?utm_source=chatgpt.com

Effects of Tocotrienols Supplementation on Markers of Inflammation and Oxidative Stress: A SystematicReview and Meta-analysis of Randomized Controlled Trials (2021)

https://pmc.ncbi.nlm.nih.gov/articles/PMC8301652/?utm_source=chatgpt.com

Investigation of the Curative Effects of Palm Vitamin E Tocotrienols on Autoimmune Arthritis Disease in vivo (2019) https://www.nature.com/articles/s41598-019-53424-7?utm_source=chatgpt.com

Regulatory Role of Vitamin E in the Immune System and Inflammation (2018) https://pmc.ncbi.nlm.nih.gov/articles/PMC7011499/?utm_source=chatgpt.com

Biological Properties of Tocotrienols: Evidence in Human Studies (2016) https://www.mdpi.com/1422-0067/17/11/1682?utm_source=chatgpt.com

Role of Immunoregulatory Transcription Factors in Differential Immunomodulatory Effects of Tocotrienols (2011) https://www.sciencedirect.com/science/article/abs/pii/S0891584911002115?utm_source=chatgpt.com

Delta- Tocotrienol Protects Mouse and Human Hematopoietic Progenitors from Gamma-Irradiation Through Extracellular Signal-regulated Kinase/Mammalian Target of Rapamycin Signaling (2010) https://haematologica.org/article/view/5806?utm_source=chatgpt.com

Dietary Supplementation with Tocotrienols Enhances Immune Function in C57BL/6 Mice (2010) https://pubmed.ncbi.nlm.nih.gov/20484546/

Daily Supplementation of Tocotrienol-rich Fraction or Alpha- Tocopherol Did Not Induce Immunomodulatory Changes in Healthy Human Volunteers (2009) https://pubmed.ncbi.nlm.nih.gov/18702848/

Tocotrienols Suppress Proinflammatory Markers and Cyclooxygenase-2 Expression in RAW264.7 Macrophages (2009) https://pubmed.ncbi.nlm.nih.gov/19655189/

γ-Tocotrienol Inhibits Nuclear Factor-κB Signaling Pathway through Inhibition of Receptor-interacting Protein and TAK1 Leading to Suppression of Antiapoptotic Gene Products and Potentiation of Apoptosis (2007) https://www.jbc.org/article/S0021-9258%2820%2979870-4/fulltext?utm_source=chatgpt.com