Oxidative Stress

Tocotrienols protect cells by directly scavenging ROS, preventing lipid damage, boosting endogenous Antioxidants, and modulating Stress-response pathways, making them powerful agents against Oxidative Stress–related diseases (neurodegeneration, cardiovascular disease, diabetes, osteoporosis, cancer).

  • Tocotrienols are 40–60 times more potent Antioxidants than Alpha-Tocopherol in Preventing Lipid Peroxidation.

  • Tocotrienols neutralize Reactive Oxygen Species (ROS) such as Superoxide Anions, Hydroxyl Radicals, and Peroxyl Radicals.

  • Tocotrienols distribute better in Lipid Bilayer Membranes (compared to Tocopherols) making them much more effective in protecting Cell Membranes from Lipid Peroxidation.

  • Tocotrienols quickly quench the chain reactions caused by Free Radicals in Oxidative Stress, by donating hydrogen atoms to Lipid Radicals, thereby protecting Membranes, LDL particles, & Mitochondrial lipids.

  • Tocotrienols upregulate Antioxidant Enzymes like SuperOxide Dismutase (SOD), Catalase, and Glutathione Peroxidase.

  • Tocotrienols increase Glutathione (GSH), the body’s master antioxidant.

  • By reducing ROS, Tocotrienols downregulate NF-κB, COX-2, and Inflammatory Cytokines, which are activated during Oxidative Stress.

  • Tocotrienols modulate Nrf2 Signaling, boosting the body’s own defense against Oxidative damage. 

  • Tocotrienols protect neurons from Oxidative Stress–induced Apoptosis.

  • Tocotrienols stabilize Mitochondria, reduce Mitochondrial ROS, and preserve ATP production.

  • Delta- and Gamma- Tocotrienols are the most effective forms of Vitamin E in Oxidative Stress reduction.

References

Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2023)

https://advances.nutrition.org/article/S2161-8313%2823%2901327-3/fulltext?utm_source=chatgpt.com

Revisiting the Therapeutic Potential of Tocotrienol (2022)

https://pmc.ncbi.nlm.nih.gov/articles/PMC9544065/?utm_source=chatgpt.com

Effects of tocotrienols supplementation on markers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials (2021)

https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0255205&utm_source=chatgpt.com

Beneficial effects of Delta- Tocotrienol against Oxidative Stress in Osteoblastic Cells: studies on the mechanisms of action (2019)

https://pmc.ncbi.nlm.nih.gov/articles/PMC7351870/?utm_source=chatgpt.com

Effects of delta-tocotrienol supplementation on liver enzymes, inflammation, oxidative stress and hepatic steatosis in patients with nonalcoholic fatty liver disease (2018)

https://pmc.ncbi.nlm.nih.gov/articles/PMC6284694/?utm_source=chatgpt.com

A Review on the Relationship between Tocotrienol and Alzheimer Disease (2018) 

https://www.mdpi.com/2072-6643/10/7/881?utm_source=chatgpt.com

The neuroprotective effects of tocotrienol rich fraction and alpha tocopherol against glutamate injury in astrocytes (2014)

https://pmc.ncbi.nlm.nih.gov/articles/PMC4333972/?utm_source=chatgpt.com

α-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons (2004) https://www.sciencedirect.com/science/article/abs/pii/S0028390804001923?utm_source=chatgpt.com