Cardiovascular Disease

Tocotrienols provide cardiovascular protection by lowering Cholesterol, reducing Inflammation, protectingArteries by Stabilizing and Reducing Arterial Plaques and protecting the Vascular Endothelium.

  • Delta- Tocotrienol inhibits the liver enzyme HMG-CoA reductase that makes Cholesterol, thus reducing total cholesterol, LDL-C, and Triglycerides, particularly in people with Hypercholesterolemia. 

  • Tocotrienols suppress NF-κB signaling and lower inflammatory cytokines (e.g., TNF-α, IL-6) that contribute to Atherosclerosis.

  • Delta- Tocotrienol reduces oxidized LDL (bad) Cholesterol, an initiator of Atherosclerotic Plaque formation. 

  • Tocotrienols may improve Endothelial function (lining of blood vessels), enhancing nNitric Oxide (NO) production and supporting Vasodilation.
    This reduces Arterial Stiffness and improves Blood Flow. 

  • Preclinical studies show Tocotrienols can reduce Atherosclerotic lesion size and stabilize plaques, lowering the risk of rupture (which can result in Heart Attacks and Strokes). 

  • Tocotrienols reduce Systolic and Diastolic blood pressure in animal models, via improved endothelial function & reduced Oxidative Stress. 

  • Some human clinical trials show LDL (Bad) Cholesterol and Triglyceride reduction with Delta-Tocotrienols. 

References

The effect of Vitamin E supplementation on serum low-density lipoprotein oxidization: A systematic review and meta-analysis of clinical trials (2025)

https://www.sciencedirect.com/science/article/abs/pii/S0014299925002456?utm_source=chatgpt.com

Effects of Tocotrienol on Cardiovascular Risk Markers in Patients With Chronic Kidney Disease: A Randomized Controlled Trial (2025) https://pubmed.ncbi.nlm.nih.gov/39840146/

Short-term intake of Delta- Tocotrienol on lipid profiles in healthy subjects (2024) https://pmc.ncbi.nlm.nih.gov/articles/PMC11782774/?utm_source=chatgpt.com

Comparative efficacy of tocotrienol and tocopherol (vitamin E) on atherosclerotic cardiovascular diseases in humans (2024) https://pubmed.ncbi.nlm.nih.gov/38948984/

Delta-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial (2023) https://www.liebertpub.com/doi/10.1089/met.2022.0052?utm_source=chatgpt.com

Revisiting the Therapeutic Potential of Tocotrienol (2022)

https://pmc.ncbi.nlm.nih.gov/articles/PMC9544065/?utm_source=chatgpt.com

Protective Effects of Tocotrienols in Cerebral and Myocardial Ischemia-Reperfusion Injury: A Systematic Review (2021) https://www.mdpi.com/2076-3417/11/17/7994?utm_source=chatgpt.com

The effects of Tocotrienol supplementation on lipid profile: A meta-analysis of Randomized ControlledTrials (2020) https://www.sciencedirect.com/science/article/abs/pii/S0965229920306890?utm_source=chatgpt.com

Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities (2018) https://pubmed.ncbi.nlm.nih.gov/29387138/

Clinical study confirms cardiovascular benefits of annatto tocotrienols (2015) https://www.nutraceuticalbusinessreview.com/clinical-study-confirms-cardiovascular-benefits-of-annatto-tocotrienols--104638?utm_source=chatgpt.com

Tocotrienols Reverse Cardiovascular, Metabolic and Liver Changes in High Carbohydrate, High Fat Diet-Fed Rats (2012) https://pmc.ncbi.nlm.nih.gov/articles/PMC3497010/?utm_source=chatgpt.com

Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics (2012) https://pubmed.ncbi.nlm.nih.gov/21918828/

Tocotrienols and cardiovascular health (2011) https://pubmed.ncbi.nlm.nih.gov/21774782/

Multifaceted role of tocotrienols in cardioprotection supports their structure: function relation (2011) https://genesandnutrition.biomedcentral.com/articles/10.1007/s12263-011-0227-9?utm_source=chatgpt.com