Cardiovascular Disease
Tocotrienols provide cardiovascular protection by lowering Cholesterol, reducing Inflammation, protectingArteries by Stabilizing and Reducing Arterial Plaques and protecting the Vascular Endothelium.
Delta- Tocotrienol inhibits the liver enzyme HMG-CoA reductase that makes Cholesterol, thus reducing total cholesterol, LDL-C, and Triglycerides, particularly in people with Hypercholesterolemia.
Tocotrienols suppress NF-κB signaling and lower inflammatory cytokines (e.g., TNF-α, IL-6) that contribute to Atherosclerosis.
Delta- Tocotrienol reduces oxidized LDL (bad) Cholesterol, an initiator of Atherosclerotic Plaque formation.
Tocotrienols may improve Endothelial function (lining of blood vessels), enhancing nNitric Oxide (NO) production and supporting Vasodilation.
This reduces Arterial Stiffness and improves Blood Flow.Preclinical studies show Tocotrienols can reduce Atherosclerotic lesion size and stabilize plaques, lowering the risk of rupture (which can result in Heart Attacks and Strokes).
Tocotrienols reduce Systolic and Diastolic blood pressure in animal models, via improved endothelial function & reduced Oxidative Stress.
Some human clinical trials show LDL (Bad) Cholesterol and Triglyceride reduction with Delta-Tocotrienols.
References
The effect of Vitamin E supplementation on serum low-density lipoprotein oxidization: A systematic review and meta-analysis of clinical trials (2025)
https://www.sciencedirect.com/science/article/abs/pii/S0014299925002456?utm_source=chatgpt.com
Effects of Tocotrienol on Cardiovascular Risk Markers in Patients With Chronic Kidney Disease: A Randomized Controlled Trial (2025) https://pubmed.ncbi.nlm.nih.gov/39840146/
Short-term intake of Delta- Tocotrienol on lipid profiles in healthy subjects (2024) https://pmc.ncbi.nlm.nih.gov/articles/PMC11782774/?utm_source=chatgpt.com
Comparative efficacy of tocotrienol and tocopherol (vitamin E) on atherosclerotic cardiovascular diseases in humans (2024) https://pubmed.ncbi.nlm.nih.gov/38948984/
Delta-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial (2023) https://www.liebertpub.com/doi/10.1089/met.2022.0052?utm_source=chatgpt.com
Revisiting the Therapeutic Potential of Tocotrienol (2022)
https://pmc.ncbi.nlm.nih.gov/articles/PMC9544065/?utm_source=chatgpt.com
Protective Effects of Tocotrienols in Cerebral and Myocardial Ischemia-Reperfusion Injury: A Systematic Review (2021) https://www.mdpi.com/2076-3417/11/17/7994?utm_source=chatgpt.com
The effects of Tocotrienol supplementation on lipid profile: A meta-analysis of Randomized ControlledTrials (2020) https://www.sciencedirect.com/science/article/abs/pii/S0965229920306890?utm_source=chatgpt.com
Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities (2018) https://pubmed.ncbi.nlm.nih.gov/29387138/
Clinical study confirms cardiovascular benefits of annatto tocotrienols (2015) https://www.nutraceuticalbusinessreview.com/clinical-study-confirms-cardiovascular-benefits-of-annatto-tocotrienols--104638?utm_source=chatgpt.com
Tocotrienols Reverse Cardiovascular, Metabolic and Liver Changes in High Carbohydrate, High Fat Diet-Fed Rats (2012) https://pmc.ncbi.nlm.nih.gov/articles/PMC3497010/?utm_source=chatgpt.com
Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics (2012) https://pubmed.ncbi.nlm.nih.gov/21918828/
Tocotrienols and cardiovascular health (2011) https://pubmed.ncbi.nlm.nih.gov/21774782/
Multifaceted role of tocotrienols in cardioprotection supports their structure: function relation (2011) https://genesandnutrition.biomedcentral.com/articles/10.1007/s12263-011-0227-9?utm_source=chatgpt.com